The museum was established in 1903 by Isabella Stewart Gardner (1840–1924), an American art collector, philanthropist, and patron of the arts. It is housed in a building designed to emulate a 15th-century Venetian palace, drawing particular inspiration from the Venetian Palazzo Barbaro.
Gardner began collecting seriously after she received a large inheritance from her father in 1891. Her purchase of Vermeer's The Concert at auction in Paris in 1892 was her first major acquisition. In 1894, Bernard Berenson offered his services in helping her acquire a Botticelli... http://en.wikipedia.org/wiki/Isabella_Stewart_Gardner_Museum